The overall aim of the project is the synthesis of novel chemo- and biocatalytic combinatorial libraries which will be screened for biological activities (e.g. as antibacterial or anticancer agents). This includues development of novel methodologies for reactions on support, either on soluble high molecular weight polymers or on solid supports together with a new class of enzymatically cleavable linkers. Enzyme cleavable linkers allow release of compounds directly into assay mixtures, because release is in aqueous medium. The application of enzymes and whole cells for a biocatalytic combinatorial approach offers the opportunity to combine functionalities in macrocyclic target structures which are difficult to obtain by tradional chemical methods.