Description of the work:

The spread of antibiotic resistance in disease-causing bacteria poses serious problems for the control of both old and new diseases. In the recent years macrocyclic compounds such as epothilone, rifamycin, vancomycin gain increasing importance as more specific drugs in antibiotic (antibacterial, antifungal etc.) and anti-cancer therapy. Active compounds contain common principles which can be used as bases for new lead compound discovery.
The present proposal aims at the synthesis of a new generation of anti-infective and anti-cancer compounds by designing and producing novel compound libraries by orchestration of polymer-supported combinatorial bio-/chemistry, together with novel strategies for screening those libraries with an "intelligent" polymer-linker system.
The work will include: